Recommendations for Clinical Trial Development in Follicular Lymphoma
نویسندگان
چکیده
منابع مشابه
Newly diagnosed and relapsed follicular lymphoma: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Diagnosis should always be based on a surgical specimen/ excisional lymph node biopsy. Core biopsies should only be performed in patients without easily accessable lymph nodes (e.g. retroperitoneal bulk). Fine needle aspirations are inappropriate for a reliable diagnosis. The histological report should give the diagnosis according to the WHO classification. Grading is performed according to the...
متن کاملESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of newly diagnosed follicular lymphoma.
• Diagnosis should always be based on a surgical specimen/ excisional lymph node biopsy providing enough material for fresh-frozen and formalin-fixed samples. To ensure adequate quality, immediate processing by an experienced pathology institute has to be guaranteed. • Fine-needle aspirations or core biopsies are inappropriate for a proper diagnosis and should only be used in the rare patients ...
متن کاملFollicular lymphoma in situ: clinical implications and comparisons with partial involvement by follicular lymphoma.
Follicular lymphoma in situ (FLIS) was first described nearly a decade ago, but its clinical significance remains uncertain. We reevaluated our original series and more recently diagnosed cases to develop criteria for the distinction of FLIS from partial involvement by follicular lymphoma (PFL). A total of 34 cases of FLIS were identified, most often as an incidental finding in a reactive lymph...
متن کاملIdiotype vaccine therapy (BiovaxID) in follicular lymphoma in first complete remission: Phase III clinical trial results.
2 Background: In previous trials, tumor-specific purified idiotype (Id) protein conjugated to keyhole limpet hemocyanin (KLH) administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induced follicular lymphoma (FL)-specific immune responses and molecular remissions (Nat Med. 1999;5:1171-7). METHODS We conducted a prospective randomized double-blind placebo-controlled multice...
متن کاملThe clinical development of obinutuzumab for the treatment of follicular lymphoma
Impressive progress has been made in recent decades for advanced-stage follicular lymphoma with the availability of anti-CD20 monoclonal antibodies, initially rituximab and more recently obinutuzumab. Obinutuzumab is a unique, third-generation, fully humanized glycoengineered IgG1 type II anti-CD20 monoclonal antibody. It has been shown to have increased antitumor activity compared to rituximab...
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ژورنال
عنوان ژورنال: Journal of the National Cancer Institute
سال: 2016
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djw255